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ERIC Number: EJ1090349
Record Type: Journal
Publication Date: 2016-Mar
Pages: 10
Abstractor: As Provided
ISSN: ISSN-0162-3257
Atypical Neural Activity in Males but Not Females with Autism Spectrum Disorder
Kirkovski, Melissa; Enticott, Peter G.; Hughes, Matthew E.; Rossell, Susan L.; Fitzgerald, Paul B.
Journal of Autism and Developmental Disorders, v46 n3 p954-963 Mar 2016
The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A