Continuing education (CE) units throughout the United States have successfully built University-to-Business (U2B) partnerships to provide greater value to their community partners and to increase revenue for the university. Our experience in building U2B partnerships and feedback from our partners--businesses, corporations, state agencies, and other organizations--indicates that an opportunity currently exists for CE units to leverage their university's comparative strengths in research and teaching to help businesses develop their employees to increase efficiency, meet strategic goals, and increase employee engagement. As is the case in building any CE area of practice, programmatic challenges must be overcome to launch and expand U2B programming. This article shares survey results from organizations about why they like to partner with universities, provides solutions to the typical challenges of building a U2B practice area, and offers a diagnostic tool to help CE managers get started in building