ERIC Number: EJ1089289
Record Type: Journal
Publication Date: 2016
Abstractor: As Provided
Oxytocin Receptor Genetic and Epigenetic Variations: Association with Child Abuse and Adult Psychiatric Symptoms
Smearman, Erica L.; Almli, Lynn M.; Conneely, Karen N.; Brody, Gene H.; Sales, Jessica M.; Bradley, Bekh; Ressler, Kerry J.; Smith, Alicia K.
Child Development, v87 n1 p122-134 Jan-Feb 2016
Childhood abuse can alter biological systems and increase risk for adult psychopathology. Epigenetic mechanisms, alterations in DNA structure that regulate the gene expression, are a potential mechanism underlying this risk. While abuse associates with methylation of certain genes, particularly those in the stress response system, no study to date has evaluated abuse and methylation of the oxytocin receptor ("OXTR"). However, studies support a role for "OXTR" in the link between abuse and adverse adult outcomes, showing that abuse can confer greater risk for psychiatric symptoms in those with specific "OXTR" genotypes. This study therefore sought to (a) assess the role of epigenetics in the link between abuse and psychopathology and (b) begin to integrate the genetic and epigenetic literature by exploring associations between "OXTR" genotypes and DNA CpG methylation. Data on 18 "OXTR" CpG sites, 44 single nucleotide polymorphisms, childhood abuse, and adult depression and anxiety symptoms were assessed in 393 African American adults (age = 41 ± 12.8 years). Overall, 68% of genotypes were associated with methylation of nearby CpG sites, with a subset surviving multiple test correction. Child abuse associated with higher methylation of two CpG sites yet did not survive correction or serve as a mediator of psychopathology. However, abuse interacted with CpG methylation to predict psychopathology. These findings suggest a role for "OXTR" in understanding the influence of early environments on adult psychiatric symptoms.
Descriptors: Child Abuse, Genetics, Symptoms (Individual Disorders), Anxiety, Depression (Psychology), Correlation, Scientific Research, Risk, Adults, Psychopathology, Physiology, Role, Mental Disorders, Prediction
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Sponsor: National Institutes of Health (DHHS)
Authoring Institution: N/A
Grant or Contract Numbers: MH071537; HD071982; MH096764; MH085806; 1008188; 19233; MH085506; P30DA027827; T32GM008169