Although previous research suggests that mood can influence creativity, the controversy about the effects of positive and negative moods has raged for years. This study investigated how the relationship between induced mood and creativity is moderated by dispositional and situational autonomy. It contrasted the different moderating effects of the 2 kinds of autonomy. In Experiment 1, 93 participants completed a questionnaire about dispositional autonomy and performed a creative task after watching 1 of 3 film clips, which were to induce positive, negative, or neutral moods. The results of experiment 1 indicated that positive moods prompted creativity and negative moods inhibited creativity when individuals were low in dispositional autonomy (low in autonomous orientation or high in impersonal orientation). In Experiment 2, 73 participants engaged in a game to manipulate levels of situational autonomy and induce positive or negative moods. The results of experiment 2 showed that positive moods fostered greater creativity than did negative moods when individuals were in full-autonomy condition. The different moderating effects of dispositional and situational autonomy are discussed.