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ERIC Number: EJ1088846
Record Type: Journal
Publication Date: 2014
Pages: 9
Abstractor: As Provided
ISSN: ISSN-1040-0419
An Exploratory Study on DRD2 and Creative Potential
Zhang, Shun; Zhang, Muzi; Zhang, Jinghuan
Creativity Research Journal, v26 n1 p115-123 2014
One critical step toward to a better understanding of creativity is to unveil its underlying genetic architectures. Recently, several studies have been conducted to investigate the effects of dopamine (DA) and 5-hydroxytryptamine (5-HT) related genetic polymorphisms on creativity. Among DA related genes, dopamine D2 receptor gene ("DRD2") is one of the most promising candidate genes for creativity. This study systematically explored the associations between "DRD2" genetic polymorphisms and creative potential in the Han Chinese population. Fifteen single-nucleotide polymorphisms (SNPs) covering "DRD2" were genotyped in 543 unrelated healthy Chinese undergraduate students whose creative potentials were assessed by divergent thinking (DT) tests. Single SNP analysis showed that, for verbal DT tests, 7 SNPs (rs4648319, rs2283265, rs1076560, rs6276, rs6279, rs6278, and rs1800497) showed significant associations with verbal fluency, and 2 SNPs (rs6277 and rs7122246) showed significant associations with verbal originality. For figural DT tests, 5 SNPs (rs2283265, rs6276, rs6279, rs6278 and rs1800497) showed significant associations with figural fluency, and 2 SNPs (rs6278 and rs1800497) showed significant associations with figural flexibility. Haplotype analysis showed that the 10-SNP haplotype consisting of rs4648319, rs4436578, rs7122246, rs2283265, rs1076560, rs6277, rs6276, rs6279, rs6278, and rs1800497 was significantly associated with verbal fluency. In conclusion, this exploratory study provides preliminary evidence for the involvement of "DRD2" in creative potential.
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Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: China
Identifiers - Assessments and Surveys: Raven Advanced Progressive Matrices
Grant or Contract Numbers: N/A