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ERIC Number: EJ1088350
Record Type: Journal
Publication Date: 2016-Feb
Pages: 11
Abstractor: As Provided
ISSN: ISSN-0162-3257
Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California
Windham, Gayle C.; Lyall, Kristen; Anderson, Meredith; Kharrazi, Martin
Journal of Autism and Developmental Disorders, v46 n2 p478-488 Feb 2016
We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th-74th percentiles = 1.21, 95% CI 1.06-1.37), and higher MSAFP (AOR = 1.21, 95% CI 1.07-1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95% CI 1.02-1.32 for < 10th percentile; AOR = 1.19, 95% CI 1.05-1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: California
Grant or Contract Numbers: N/A