This study explores the influence of school culture on the management of professional development in secondary schools in Malaysia. It illustrates how school culture influences the school professional development management. The instrument used in this study is a self-administered questionnaire involving 515 secondary school teachers. The results of the study reveal that school culture correlates with the management of professional development and found that two out of five (40%) constructs of school culture influence the school professional development management. This finding shows that only two constructs of school culture, namely collective efficacy and communication, can become predictors of the management of professional development in schools. This study has clearly shown the importance of school culture to management of professional development in secondary schools. As for the contribution to the body of knowledge, this study has introduced a new construct, identified as Total Evaluation, to evaluate the management for professional development. This will help improve the existing measurement currently used.