This qualitative study investigated the perceptions and challenges of Seventh-day Adventist teachers towards inclusion classrooms in the United States. For this study, 17 participants were interviewed using two 12-item interview protocols. The analysis of the teachers' responses revealed five key perceptions. First, teachers have positive attitudes towards inclusion. Second, accommodations help students who are mildly disabled succeed in the regular classroom. Third, inclusion classrooms can be Christian based. Fourth, school personnel need to develop policies for accepting students with disabilities. Finally, Adventist teachers can identify children with special needs. Participants identified two challenges for implementing inclusion classrooms, first, developing policies and resources for use by teachers, and second, providing needed training to help teachers succeed in an inclusive classroom. The article concludes with recommendations for developing a successful inclusive educational program in Christian schools and recommendations future study.