Background: Stroke is a leading cause of disability. Rehabilitation aims to hasten and maximize recovery from stroke by treating the disabilities caused by the stroke. Therefore, the aim of this study determine the post stroke patients' knowledge and practices in relation to disease and activities of daily living before the implementation of stroke rehabilitation and examine the effect of stroke rehabilitation on stroke patients' knowledge and practices in relation to disease and activities of daily living strategies. To fulfill the aim of these study three research hypotheses were formulated; Quasi-experimental research design was utilized to fulfill the aim of this study. The study sample included 60 male and female adult patients with stroke they were allocated randomly into two groups, study and control (30 patients each) the sitting Rheumatology and Rehabilitation Department at Minia University Hospital. Four tools were utilized for data collection; socio-demographic and medical data sheet, pre/post knowledge questionnaire interview schedule, Barthel index scale, Ashworth scale and Construction patient teaching booklet about stroke and activities of daily living performance. Before, immediate post test, after two month. Results of the study documented a significant improvement in knowledge and practices post strategies in study group in addition to reaching of an optimum level of independence for daily activities living and improvement degree of spasticity in study group more than control group, . In conclusion, education of stroke patient is necessary to achieve an optimum level of functioning. Replication of this study on larger probability sample is highly recommended.