Evidence-based practice related to autism research is a controversial topic. Governmental entities and national agencies are defining evidence-based practice as a specific set of interventions that educators should implement; however, large-scale efforts to generalize autism research, which are often single-subject case designs, may be a setback in the field. Children on the autism spectrum can experience a very broad range of difficulties with social interactions, managing behaviors, and communicating; similarly, they may experience a wide range of comorbidities. In addition, different environmental considerations come into play for each child. Such challenges to generalizing research are important to acknowledge so that research will be used to inform, not to dictate, the interventions that educators select. The process of identifying and implementing evidence-based practices for children with autism spectrum disorders is a dynamic one that requires educators to adapt interventions to meet students' individual needs.