Background: Organizational factors are considered to be the cornerstone in achieving psychological and professional security at work, which in turn are positively reflected in job performance both quantitatively and qualitatively. Aim of the Study: The study aimed to assess of selected organizational factors (workload, available recourses and manager support) affecting nurses performance in northern region of the West Bank governmental hospitals to improve its current and future performance of professional nurses. Subjects and Methods: A quantitative descriptive study utilized stratified random sampling of 185 nurses. A self administered questionnaire was developed with a response rate of 97%. The questionnaire was validated by experts, and reliability was obtained by Cranach's alpha coefficient was (0.863) Data were analyzed using SPSS. Results: The overall level of selected organizational factors affecting performance of professional nurses was high (74.6 %); the workload rated the highest (79.2 %) among the study dimensions as perceived by nurses, manager support (72.0%), and resources availability (69.8%). Also it was found that there are significant differences at a = 0.05 between the total score due to workplace between Thabet Thabet hospital and Rafedia hospital, in favor Rafedia hospitals. Conclusion and Recommendation: The findings of this study provide recommendations and suggestions to improve the performance of professional nurses in governmental hospitals such as: managers should ensure adequate number of staff and qualification according to work condition and sufficient number of professional nurses in the hospital at all times and shifts.