Extension programs based on identified needs, relevant theory, and solid research too often fail to realize their objectives. Program implementation is acknowledged to contribute to program effectiveness, yet systematic attention has not been paid to the array of implementation issues that can complicate achieving program goals. We developed the multilevel Implementation Issues Framework (IIF) to guide the identification and analysis of factors contributing to the ability of a program model to achieve its intended outcomes. The IIF can be used to complement logic models, inform process evaluation efforts for new and multisite programs, and support the implementation of evidence-based programming.