ERIC Number: EJ1082449
Record Type: Journal
Publication Date: 2015-Dec
Abstractor: As Provided
Reference Count: 47
Maternal Infection during Pregnancy and Autism Spectrum Disorders
Zerbo, Ousseny; Qian, Yinge; Yoshida, Cathleen; Grether, Judith K.; Van de Water, Judy; Croen, Lisa A.
Journal of Autism and Developmental Disorders, v45 n12 p4015-4025 Dec 2015
We conducted a nested case-control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal infections during pregnancy and risk of autism spectrum disorders (ASD). Cases, controls, and maternal infections were ascertained from Kaiser Permanente Northern California clinical databases. No overall association between diagnoses of any maternal infection during pregnancy and ASD was observed [adjusted odds ratio (OR[subscript adj]) = 1.15, 95 % confidence interval (CI) 0.92-1.43]. However, women with infections diagnosed during a hospital admission (OR[subscript adj] = 1.48, 95 % CI 1.07-2.04), particularly bacterial infections (OR[subscript adj] = 1.58, 95 % CI 1.06-2.37), were at increased risk of delivering a child with ASD. Multiple infections during pregnancy were associated with ASD (OR[subscript adj] = 1.36, 95 % CI 1.05-1.78).
Descriptors: Autism, Pervasive Developmental Disorders, Mothers, Pregnancy, Diseases, Prenatal Influences, Case Studies, Risk, Clinical Diagnosis, Correlation
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Location: California