The relevance of any university education depends on quality parameters that should be specified, adhered to and sustained. The development of quality assurance culture in Nigerian university education is imperative, considering the fact that globalization, mobility of labour, competition and the quest for best practices have subjected universities to international comparison. This article, therefore, examines the various key parameters bothering on developing and sustaining quality assurance culture in Nigerian universities, and explores strategies aimed at improving and sustaining a quality culture at the university level. Furthermore, it proposes a quality assurance model for Nigerian universities, and concludes that institutional paradigm shift towards a quality culture is imperative for sustainable university education in Nigeria.