In Socialist market economy, the characteristics of economic development tend to vary in different regions. Accordingly, enterprise education on college students has to be combined with regional economic features, particularly with a profound knowledge about the characteristics of local entrepreneurs. Insufficient resources and inconvenient geographical location set a special human environment for Wenzhou. Influenced by such an environment, the entrepreneurs in Wenzhou who initiated their business at the initial stage have developed some special spirits such as survival of the fittest, daring to outperform others, practical spirit, utility orientation, teamwork and so on. College students in Wenzhou are also expected to carry forward these spirits and absorb the essence in them to improve their enterprise qualities.