Before giving students permission to construct and test their designs, students must understand how to use hazardous tools, machines, and chemicals in a safe manner. Students often complain that they have already seen the safety videos and passed the same safety tests in prerequisite Integrative STEM Education (I-STEM Ed) courses. Although they may have previously used similar equipment and handled hazardous chemicals, teachers still have a duty to instruct and demonstrate the safer operation of each tool and machine, and handling of hazardous chemicals. This article presents six strategies to make safety instruction more engaging and fun for both the students and the instructor. Most importantly, the strategies presented in this article can be used for more effective ways to teach safety concepts in T&E, science, and CTE (career and technical education) laboratories to develop safer STEM-literate citizens (Love, 2015a). Although all of the strategies described in this article can help to promote safer I-STEM Ed learning environments, instructors should keep in mind that none of these strategies can replace their expertise developed from training and laboratory experience. Even if students conduct safety evaluations and laboratory inspections, the instructor is still liable for maintaining a safe learning environment at all times.