Motivation involves both extrinsic and intrinsic types. One must intrinsically be motivated before accepting a new challenges followed by intrinsic motivation for best achievement. In this study, the researcher used census sampling technique whereby all 85 respondents were used for the case study as a result of the fairly small total population of respondents. The researcher used both primary and secondary sources in gathering data. The data used in compiling this work have been gathered from the staff and management of Ghana Senior High School, through the administration of questionnaires and personal interviews. The data views and responses of the staff and management, were analyzed and interpreted to find out the influence of motivation on teachers in the school in question. Findings of the study revealed job enrichment and merit pay as requirements for increasing the motivation of teachers of Ghana Senior High School-Koforidua. The researcher suggests that effective strategies such as job enrichment and merit pay could adequately be implemented by management to increase the motivation of teachers at Ghana Senior High School-Koforidua.