This study aims to examine the positive impact of The Holy Quran based on the laugh and smile. This kind of derivatives in which context of praise, expression the feeling of happiness and joyful in the positive senses. Everyone needs to relieve his heart so that happiness and joy on their faces can be seen. Laughter also are some of attribute towards the Almighty Allah which was inherent of the prophet muhammed pbuh. He was always smiling at anyone whom he met. The smile is the best medicine of having the quality of work in life as well as success in overcome the challenge in life.