University is one of the places where a systematically organized and scientifically oriented education is offered. It is through such an organized manner that the knowledge, skill and desired attitude of the learner develop, but in a given class it is sometimes seen that there is a difference in achievement as a result of different factors that affect the academic achievement of students. This study was conducted to examine different factors influencing the academic performance of students in higher institution case of Rift valley university Jimma campus Ethiopia. Cross sectional study design was examined. The respondents for this study was 294 students which is determined using simple random sampling technique. A survey was conducted by using a questionnaire for information gathering about different factors relating to academic performance of students. Chi-square test of association and regressions was applied to investigate the effect of different factors on students' achievement.