The study discusses improving safe blood donation in Nigeria and the roles of the mass media in achieving same in Nigerian hospitals. In this regard, it answers the questions: What is blood? What is blood donation? And is safe blood donation adequate in Nigeria? Beyond the relevant answers given on the above questions, it also explains the roles of mass media in improving safe blood donations among Nigerians. Besides this, it recommends among others that the federal government, state government, private hospitals and concerned Nigerians should encourage mass media campaigns continuously on the need for safe blood donations to save lives. It also upholds that the federal and state governments should establish more blood banks in their health facilities, in order to spur the people, who would become aware through the mass media, to access same for safe blood donations.