Health care systems in many countries are moving towards outpatient care in which family members are central in providing care for patients with life-threatening illness. Family members and friends haven't knowledge and skills to become caregivers as many studies found that, the need to involve in such program to enhance their ability to be caregivers. This study contacted to know the effect of home caregiving program for family members providing care for chronically ill relative client, A quasi-experimental was conducted at hospital and health center for follow up or taking medications in Babylon city, including an intervention group and control group. A four-week follow-up assessment were performed in each group. The sample of study was taken accidentally from (60) families who had chronic disease or older clients in different socioeconomic and educational level, The participants showed little score regarding knowledge they had 15 out of 25 score about (46.7 percent) While in practice they had 19 out 40 score (41.7 percent). When they answered the M C Q questions about the knowledge necessary for home caring. In practice, chick list used for determined the ability of caring regarding educational program. An educational program for family caregivers is important to enhance the ability of caring outside hospital.