ERIC Number: EJ1078645
Record Type: Journal
Publication Date: 2015-Nov
Abstractor: As Provided
Overactive Pattern Separation Memory Associated with Negative Emotionality in Adults Diagnosed with Autism Spectrum Disorder
South, M.; Stephenson, K. G.; Nielson, C. A.; Maisel, M.; Top, D. N.; Kirwan, C. B.
Journal of Autism and Developmental Disorders, v45 n11 p3458-3467 Nov 2015
Bowler et al. ("Journal of Autism and Developmental Disorders" 44(9):2355-2362. doi:10.1007/s10803-014-2105-y, 2014) have suggested that a specific memory impairment in autism spectrum disorders (ASD) arises from hippocampal failure to consolidate multiple related pieces of information. Twenty-four adults diagnosed with ASD and matched healthy controls completed a pattern separation memory task that is known to critically depend on hippocampal involvement. They additionally completed questionnaires regarding anxiety, depression, and behavioral motivation. Specific deficits in pattern separation were significantly correlated with negative emotionality; the best predictor of memory deficit was from a measure of achievement motivation that has also been associated with hyperactivity and impulsivity. In the context of impaired emotion regulation in ASD, there is a need for integrated cognitive, affective, and neural systems approaches to build targeted interventions.
Descriptors: Autism, Pervasive Developmental Disorders, Adults, Memory, Brain, Task Analysis, Questionnaires, Anxiety, Depression (Psychology), Motivation, Psychological Patterns, Negative Attitudes, Predictor Variables, Self Control, Emotional Disturbances, Intervention, Achievement
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Publication Type: Journal Articles; Reports - Evaluative
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