Autonomous inquiry learning is a kind of learning model, which relies mainly on learners and emphasizes that learners should inquire knowledge actively; moreover, ESP, which emphasizes the combination of language learning and specific purposes learning, is a goal-oriented and well targeted instruction system. Therefore, ESP and autonomous inquiry can be mixed to construct a new model of instruction, which makes the learners explore and construct the knowledge as well as solving problems through acquired knowledge. The ability of autonomous learning will be strengthened. Meanwhile, English language teaching and professional skills can be mixed as well, so the performance of college English instruction can be improved significantly and the needs of national economic development and international communication can be met.