This paper presents the methodology and results of teaching an entire engineering course using challenge-based instruction. The challenges consisted of eight biomechanics multimedia learning modules developed by the authors as part of a broader NSF educational coalition. The biomechanics modules were presented in an undergraduate mechanical engineering course titled "Biomechanics of Human Movement." The class (N = 18) was divided into three-member teams. Each team performed the eight computer-based assignments in intervals of one-two weeks per challenge during the semester. Pre-tests, post-tests, affect surveys, a biomechanics topics matrix, and student outcomes surveys were conducted during the course to determine the success of this approach. This paper outlines the challenge-based approaches used and presents assessment methods for a full, semester-long course. Thus, it is directed at faculty who may wish to use this interesting approach in their own engineering courses.