Despite the growing introduction of inclusive education, children with profound intellectual and multiple disabilities (PIMD) are barely included. Because an underlying factor here may be the attitudes of those directly involved, the present study focuses on the attitude of parents and relating variables concerning experience with individuals with disabilities. A self-report questionnaire was completed by 190 parents of children attending general primary schools in the north of the Netherlands. Although parents showed an overall positive attitude, they were most negative about the inclusion of children with PIMD. In addition, no "experience with individuals with disabilities" was slightly negatively associated with the parents' attitudes. To overcome barriers of the inclusion of children with PIMD, such as negative parental attitudes, the outcomes of the present study are discussed in the light of possible interventions.