The present study aimed to study the effect of business education on the attitudes of the secondary school male student towards major selection. The population of the study were all male secondary students in Isfahan in the year 2013/2015. The sample was a group of 44 students were placed in the experimental and 44 in the control group. In this study, the researcher-made questionnaire was used which involved 5 dimensions, i.e., personal interest, usefulness, job market, available facilities and encouragement by society. In this study, business skills were taught during eight 75-min sessions, depending on the students' tiredness, curriculum and general conditions of the schools. The results of the independent samples T-test showed that there is a significant difference between the student's attitudes towards major selection in each of the experimental and control groups (p<0.05). Therefore, the experimental group got higher scores in each of the following dimensions: personal interest, usefulness, job market, available resources and encouragement by society. Thus, they can have a more realistic view of major selection and take into consideration more factors.