This article describes an arts- and spatial thinking skill--integrated inquiry project applied to life science concepts from the Next Generation Science Standards for fourth grade students that focuses on two unifying or crosscutting themes: (1) structure (or "form") and function and (2) use of models. Students made observations and photographs of common wild mammals that lived near their homes, such as squirrels, rabbits, deer, groundhogs, and opossums. They then created a three-dimensional diorama to showcase models of the various structures and functions that help the animals survive. These models included a papier-mâché model of the animal's home with explanations of its form and functions, acrylic polymer clay models of the animal, a student-drawn computer generated fold-up model of the animal in a natural history scene, models of the animal's dentition, and models of its skull made from recycled plastic bottles. Student comments, photographs of example finished products, a chart of spatial thinking skills addressed by the project, and a rubric for scoring this successful project are included.