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ERIC Number: EJ1074391
Record Type: Journal
Publication Date: 2015-Sep
Pages: 4
Abstractor: As Provided
ISSN: ISSN-0021-9584
Synthesis of a Biologically Active Oxazol-5-(4H)-One via an Erlenmeyer-Plo¨chl Reaction
Rodrigues, Catarina A. B.; Martinho, Jose´ M. G.; Afonso, Carlos A. M.
Journal of Chemical Education, v92 n9 p1543-1546 Sep 2015
The synthesis of (Z)-4-(4-nitrobenzylidene)-2- phenyloxazol-5(4"H")-one, which is a potent immunomodulator and tyrosinase inhibitor, is described as an experiment for an upper-division undergraduate organic chemistry laboratory course. This compound is produced via an Erlenmeyer-Plo¨chl reaction in the absence of any additional solvents and is isolated without need of preparative chromatography, yielding up to 97% of product.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A