ERIC Number: EJ1074391
Record Type: Journal
Publication Date: 2015-Sep
Abstractor: As Provided
Reference Count: 30
Synthesis of a Biologically Active Oxazol-5-(4H)-One via an Erlenmeyer-Plo¨chl Reaction
Rodrigues, Catarina A. B.; Martinho, Jose´ M. G.; Afonso, Carlos A. M.
Journal of Chemical Education, v92 n9 p1543-1546 Sep 2015
The synthesis of (Z)-4-(4-nitrobenzylidene)-2- phenyloxazol-5(4"H")-one, which is a potent immunomodulator and tyrosinase inhibitor, is described as an experiment for an upper-division undergraduate organic chemistry laboratory course. This compound is produced via an Erlenmeyer-Plo¨chl reaction in the absence of any additional solvents and is isolated without need of preparative chromatography, yielding up to 97% of product.
Descriptors: Organic Chemistry, Hands on Science, College Science, Undergraduate Study, Science Experiments, Scientific Concepts, Molecular Structure, Science Laboratories, Laboratory Experiments
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: firstname.lastname@example.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education; Postsecondary Education
Authoring Institution: N/A