ERIC Number: EJ1074373
Record Type: Journal
Publication Date: 2015-Oct
Abstractor: As Provided
Reference Count: 23
Corpus Callosum Area and Brain Volume in Autism Spectrum Disorder: Quantitative Analysis of Structural MRI from the ABIDE Database
Kucharsky Hiess, R.; Alter, R.; Sojoudi, S.; Ardekani, B. A.; Kuzniecky, R.; Pardoe, H. R.
Journal of Autism and Developmental Disorders, v45 n10 p3107-3114 Oct 2015
Reduced corpus callosum area and increased brain volume are two commonly reported findings in autism spectrum disorder (ASD). We investigated these two correlates in ASD and healthy controls using T1-weighted MRI scans from the Autism Brain Imaging Data Exchange (ABIDE). Automated methods were used to segment the corpus callosum and intracranial region. No difference in the corpus callosum area was found between ASD participants and healthy controls (ASD 598.53 ± 109 mm[superscript 2]; control 596.82 ± 102 mm[superscript 2]; p = 0.76). The ASD participants had increased intracranial volume (ASD 1,508,596 ± 170,505 mm[superscript 3]; control 1,482,732 ± 150,873.5 mm[superscript 3]; p = 0.042). No evidence was found for overall ASD differences in the corpus callosum subregions.
Descriptors: Brain Hemisphere Functions, Autism, Diagnostic Tests, Comparative Analysis, Control Groups, Experimental Groups, Pervasive Developmental Disorders, Statistical Analysis
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A