ERIC Number: EJ1074355
Record Type: Journal
Publication Date: 2015-Oct
Abstractor: As Provided
Reference Count: 57
Brief Report: Systematic Review of Rett Syndrome in Males
Reichow, Brian; George-Puskar, Annie; Lutz, Tara; Smith, Isaac C.; Volkmar, Fred R.
Journal of Autism and Developmental Disorders, v45 n10 p3377-3383 Oct 2015
Rett syndrome (RTT) is a neurogenetic disorder in which a period of typical development is followed by loss of previously acquired skills. Once thought to occur exclusively in females, increasing numbers of male cases of RTT have been reported. This systematic review included 36 articles describing 57 cases of RTT in males. Mutations of the MECP2 gene were present in 56% of cases, and 68% of cases reported other genetic abnormalities. This is the first review of published reports of RTT in male patients.
Descriptors: Genetic Disorders, Neurological Impairments, Child Development, Gender Differences, Literature Reviews, Males, Genetics
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Publication Type: Journal Articles; Information Analyses; Reports - Evaluative
Education Level: N/A
Authoring Institution: N/A