The purpose of this study was to investigate teachers' use of ICT and the factors that affect their ICT use in secondary schools in Ghana. A focus group interview was used to gather data from participants. Ten groups of six students each from urban, semi-urban and rural schools were chosen for the focus group interviews. The results of this study have shown that teachers' way of teaching is still teacher-centred. They mainly use ICT for organizational and informative purposes. Teachers' limited use of ICT in teaching is attributed to lack of technological resources (i.e. hardware, software and the internet) and school leadership support for the teachers in schools.