ERIC Number: EJ1073003
Record Type: Journal
Publication Date: 2015-Sep
Abstractor: As Provided
Reference Count: 62
Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism
Travers, Brittany G.; Bigler, Erin D.; Tromp, Do P. M.; Adluru, Nagesh; Destiche, Dan; Samsin, Danica; Froehlich, Alyson; Prigge, Molly D. B.; Duffield, Tyler C.; Lange, Nicholas; Alexander, Andrew L.; Lainhart, Janet E.
Journal of Autism and Developmental Disorders, v45 n9 p3030-3040 Sep 2015
Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5-33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem's corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD.
Descriptors: Brain Hemisphere Functions, Autism, Symptoms (Individual Disorders), Severity (of Disability), Males, Comparative Analysis, Children, Adolescents, Adults, Diagnostic Tests, Muscular Strength, Psychomotor Skills, Predictor Variables
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A