This article examines the literature regarding prevention and intervention programs that are aimed at supporting student mental health. It will also examine the practical use of these types of programs in schools, as reflected by the experiences of the MindMatters Plus demonstration schools. The aim of the MindMatters Plus initiative is to build the capacity of secondary schools to increase their support of students with high mental health needs. The implementation of programs that support student mental health is one component of this whole school aim that includes the embedding of a range of strategies to support students with high mental health needs, creating processes that effectively identify students at risk, and the building of community partnerships. As will be demonstrated, the use of intervention and prevention programs in schools can be an effective way of positively supporting student mental health that can be successfully integrated into the school curriculum.