ERIC Number: EJ1069024
Record Type: Journal
Publication Date: 2015-Jul
Abstractor: As Provided
Introducing Organic Chemistry Students to Natural Product Isolation Using Steam Distillation and Liquid Phase Extraction of Thymol, Camphor, and Citral, Monoterpenes Sharing a Unified Biosynthetic Precursor
McLain, Katherine A.; Miller, Kenneth A.; Collins, William R.
Journal of Chemical Education, v92 n7 p1226-1228 Jul 2015
Plants have provided and continue to provide the inspiration and foundation for modern medicines. Natural product isolation is a key component of the process of drug discovery from plants. The purpose of this experiment is to introduce first semester undergraduate organic chemistry students, who have relatively few lab techniques at their disposal, to the process of natural product isolation. In one, 3 h lab period, students use steam-distillation and liquid-phase extraction to isolate a single medicinally relevant molecule from one of three plants. The identity of the molecule can be demonstrated using infrared spectroscopy and thin-layer chromatography. Students choose to isolate thymol from thyme ("Thymus vulgaris"), citral from lemongrass ("Cymbopogen"), or camphor from sagebrush ("Artemisia tridentata")--three commercially available plants with a long history of use. Each isolated molecule has a common biosynthetic origin in the plant, and this is discussed to introduce the relationship between organic chemistry and biochemistry.
Descriptors: Organic Chemistry, Science Instruction, Plants (Botany), Molecular Structure, Science Experiments, College Science, Undergraduate Study, Science Laboratories, Laboratory Experiments, Spectroscopy, Science Process Skills, Biochemistry, Pharmacology
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: firstname.lastname@example.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Authoring Institution: N/A
Grant or Contract Numbers: N/A