The sustained phase of transition to economies characterised by considerable, and sometimes revolutionary, advances in science, technology and related industries, coupled with subsequent profound changes in economy and society, has increased the importance of the knowledge-intensive phases of production for value-creation. As enterprises, in fact, become more reliant on technology, they will become more dependent on knowledge. Accordingly, policy makers in a growing number of countries have become increasingly concerned with the management of the entire knowledge chain: from creation to the diffusion, conversion and entrepreneurial exploitation of scientific and technological knowledge. The knowledge chain also has profound implications for higher education institutions and business schools, which to be successful, need to help companies create knowledge and become part of knowledge streams. To secure a better future for knowledge flow between universities and firms, knowledge transfer (KT) needs trustful and outward-looking knowledge brokers with excellent interpersonal skills, commercial awareness, and contractual experience. Trust is a critical component of the business formula for those who should build bridges in a field so subtle and ambiguous as that of transferring know-how, know-what, know-why, know-whom, know-when. For the foreseeable future, KT advancements would not be imperilled in as much as arrangements for KT are likely to be made within a frame of reference that fits with the enterprising role of knowledge intermediaries organized in trust-promoting groups. These groups could play a greater role in building sustainable relationships between the academic community and the business sector, with an emphasis on SMEs.