Decreasing of interest in mathematics and science subjects among students in Malaysia has been discussed lately. Applications of mathematics and science in real world settings might be able to facilitate increased interests in the subjects, especially in doing research. Therefore, the aim of this paper is to manifest that learning mathematics through project-based activity would cultivate interest in students towards research and foster research-like skill. Experience of teaching mathematics in School of Mathematical Sciences, UKM with integration of biological and physics problems are discussed. The level of interest is measured through students' interest in doing their research projects in the final semester of the undergraduate study. The percentage of students interested in doing applied problems showed an increased in number. Thus it is concluded that the project-based activity led the students to identify their interest and hence head their interest into research.