Humor is an often neglected but potentially powerful tool in college counseling center interventions. In this article we review potential benefits and hazards of using humor in a college mental health setting along with perspectives on humor's mechanism of action and distinctions between types of humor. Therapist and client-specific considerations, such as culture and identity, are discussed in relation to the judicious use of humor in individual therapy. Based on our experience employing these techniques at an urban, private university counseling center, we make specific recommendations for the application of humor in therapy, the counseling center environment, and outreach materials.