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ERIC Number: EJ1067296
Record Type: Journal
Publication Date: 2015-Jun
Pages: 11
Abstractor: As Provided
Reference Count: 31
ISBN: N/A
ISSN: ISSN-0021-9584
Using Green Star Metrics to Optimize the Greenness of Literature Protocols for Syntheses
Duarte, Rita C. C.; Ribeiro, M. Gabriela T. C.; Machado, Adélio A. S. C.
Journal of Chemical Education, v92 n6 p1024-1034 Jun 2015
A procedure to improve the greenness of a synthesis, without performing laboratory work, using alternative protocols available in the literature is presented. The greenness evaluation involves the separate assessment of the different steps described in the available protocols--reaction, isolation, and purification--as well as the global process, with the tool green star. This proved to be adequate to assess separately the microgreenness of the steps. Two case studies, the syntheses of ethyl acetate and manganese(III) acetylacetonate, are presented. The results show how the different steps limit the global greenness of the synthesis and suggest that the workup may be more problematic than the reaction itself. Moreover, the study showed that the green star can be used for comparing in detail the alternative protocols proposed for a synthesis, finding the best alternative for each step and allowing the design of a greener protocol by combining them.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Research
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: Portugal