The purpose of this study was to identify factors that may protect or insulate people from engaging in nonsuicidal self-injury (NSSI). College students (N = 14,385) from 8 universities participated in a web-based survey. Results of bivariate correlations and multiple regression revealed that spirituality/religiosity, life satisfaction, and life meaning were predictive of NSSI. The authors provide practice suggestions for college counselors and other professionals charged with helping those at risk for NSSI.