Globalization brings change in all aspect of human life, including in how job and organizations operate. These changes create strain and stress not only among employee at business organization, but also among academic staff. The dean of faculty or department at university has important role in prevent the effects of job stress among the academic staff by giving support, motivation, and redesign how a task should be finished to reduce job stress. This study aims to examine the role of leadership practices with job stress among Malay academic staff. Design of this study is survey research with quantitative approach. A total of 124 academic staff participate or answered the questionnaires. The data was analyzed with structural equation model method using Amos 18 program. The result of structural equation modeling suggests that four dimensions of leadership practices show unique relationship pattern with four dimensions of job stress. The significant relationship between exogenous and endogenous was tested using structural equation modeling (SEM). The result of SEM analysis just confirms three exogenous variables that significantly have relationship with endogenous variables. Those are dimension of challenging the process with behavioral, emotional, physiologic and cognitive stress responses. Enabling others to act with emotional stress response, and the last, encouraging the heart with behavioral stress response. While inspiring a shared vision is not have significant relationship with all dimension of job stress. Overall, the proposed model had a fit model with empirical data. The mechanism of relationship among exogenous and endogenous variables will be discussed in a paper below.