Increasing episodes of campus violence have warranted an investigation into college students' perception of safety on campus. In this study, 56,811 students responded to the Core Alcohol and Drug Survey during the 2010 academic school year. Numerous universities administered the survey and students completed the survey either in class or electronically. More than 92% of non-drinkers (n = 19,481) felt safe on campus compared to 94% of drinkers (n = 31,443). A higher proportion of non-drinkers (almost 8%, n = 1,603) felt unsafe compared to those who drink alcohol (about 6%, n = 1,998). After adjusting for gender, race/ethnicity, and place of residence, students who felt unsafe on campus had 20% less odds of drinking compared to students who felt safe. Students who drink may have a false sense of security, take unnecessary risks, or place themselves in dangerous situations. These findings confirm the need for education and awareness campaigns among college students to reduce victimization and perpetration related to alcohol use.