Response to Intervention (RtI) provides a framework for effective prevention and intervention at all achievement levels. RtI also allows school districts to use an alternative method for identifying students with disabilities, but there is a paucity of published empirical research aimed to inform RtI best practices among general educators. The purpose of this paper was to systematically review empirical RtI research with regard to research dissemination and specific foundational components. Specifically, 47 peer-reviewed articles describing policy, intervention, or tiered supports within RtI were reviewed for content related to the six foundational RtI components: (a) screening, (b) primary prevention, (c) secondary intervention, (d) tertiary intervention, (e) progress monitoring, and (f) multidisciplinary evaluation. The findings suggest most RtI research is conducted within the context of special education, and the subsequent articles are published in special education journals. Therefore, additional RtI research outlining evidence-based practices for the primary and secondary tiers of RtI need be disseminated to administrators and general educators, specifically focusing on all six implementation components.