Many business schools or colleges require calculus as a prerequisite for certain classes or for continuing to upper division courses. While there are many studies investigating the relationship between performance in calculus and performance in a single course, such as economics, statistics, and finance, there are very few studies investigating the relationship between calculus and performance in upper division as a whole. In this paper, a general linear model was used to assess this less studied relationship. The findings suggest a positive relationship between calculus and upper division performance and gender differences in the relationship between the number of tries to pass calculus and upper division performance.