A group of 20 practicing teachers were asked to define "unteachable" students. Their answers range from "students who lack interest, those facing problems in learning, those who refuse to accept changes, students who find it difficult to learn in formal environments, those who are unpredictable, defiant, show no interest in self learning, hyperactive, no patience to sit and listen, have short attention span, and are difficult to teach especially those with low IQ." This article asks the question: Who will teach these children? Oftentimes they are left to their own devises, passed off as "difficult to deal with" and "hopeless," especially struggling ones. Teaching them is no small task and quality teaching seems to be at the core of the solution to the challenge of making a meaningful difference for all these students. This paper focuses on teachers who succeed in teaching students that may be considered unteachable, the key ingredients and attributes that help certain teachers nurture and inspire this group of students to succeed, and the 5 kinds of knowledge that are relevant to this success.