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ERIC Number: EJ1062566
Record Type: Journal
Publication Date: 2015-Jun
Pages: 10
Abstractor: As Provided
Reference Count: 42
ISSN: ISSN-0162-3257
Brief Report: Anomalous Neural Deactivations and Functional Connectivity during Receptive Language in Autism Spectrum Disorder--A Functional MRI Study
Karten, Ariel; Hirsch, Joy
Journal of Autism and Developmental Disorders, v45 n6 p1905-1914 Jun 2015
Neural mechanisms that underlie language disability in autism spectrum disorder (ASD) have been associated with reduced excitatory processes observed as positive blood oxygen level dependent (BOLD) responses. However, negative BOLD responses (NBR) associated with language and inhibitory processes have been less studied in ASD. In this study, functional magnetic resonance imaging showed that the NBR in ASD participants was reduced during passive listening to spoken narratives compared to control participants. Further, functional connectivity between the superior temporal gyrus and regions that exhibited a NBR during receptive language in control participants was increased in ASD participants. These findings extend models for receptive language disability in ASD to include anomalous neural deactivations and connectivity consistent with reduced or poorly modulated inhibitory processes.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: US Army (DOD); National Institutes of Health (DHHS)
Authoring Institution: N/A
Identifiers - Location: New York
Grant or Contract Numbers: RDECOM-TARDEC W56H2 V-04-P-L|RO1NS0 56274