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ERIC Number: EJ1062407
Record Type: Journal
Publication Date: 2015-May
Pages: 8
Abstractor: As Provided
Reference Count: 24
ISSN: ISSN-0021-9584
Metalloprotease Peptide Inhibitors: A Semester-Long Organic Synthetic Research Project for the Introductory Laboratory Course
Pontrello, Jason K.
Journal of Chemical Education, v92 n5 p811-818 May 2015
A semester-long research project to synthesize unique compounds designed after published metalloprotease peptide inhibitors is presented. The research project encompasses a set of nine organic chemistry reactions traditionally taught in the second semester lab course, and the procedures are derived from scientific literature. The two principle goals of the course design are (1) to enhance student interest through the scientific applications of the research project and (2) to introduce students to a synthetic organic chemistry research experience to develop skills needed in this area. In addition to the exploratory synthesis of novel compounds, students read background review articles about metalloprotease inhibitors. The design of the project provides opportunity for collaboration over multiple years, between different courses within the university, and among different schools.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: Massachusetts