NotesFAQContact Us
Collection
Advanced
Search Tips
Peer reviewed Peer reviewed
Direct linkDirect link
ERIC Number: EJ1062392
Record Type: Journal
Publication Date: 2015-May
Pages: 4
Abstractor: As Provided
Reference Count: 15
ISBN: N/A
ISSN: ISSN-0021-9584
An Integrated Approach to Thermal Analysis of Pharmaceutical Solids
Riley, Shelley R. Rabel
Journal of Chemical Education, v92 n5 p932-935 May 2015
A three-tiered experiment for undergraduate Instrumental Analysis students is presented in which students characterize the solid-state thermal behavior of an active pharmaceutical ingredient (acetaminophen) and excipient (a-lactose hydrate) using differential scanning calorimetry, thermogravimetric analysis, and thermal microscopy. Students are required to perform qualitative and quantitative analysis, incorporating data from the three thermal analysis techniques to successfully interpret melting, decomposition, and dehydration thermal transitions. Students use thermal analysis software to determine transition temperatures and enthalpies of transitions, and use stoichiometric calculations to calculate the water of hydration.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A