Since the 1990s, the development in the international dimension of higher education including student/scholar mobility, regional and international research networks and initiatives have brought new opportunities for African higher education to be incorporated in the global knowledge production and circulation processes. One of the instruments of internationalization process that facilitates international knowledge flows in the knowledge society is academic mobility. This research will touch upon the major issues related to student mobility in Africa since the 1990s addressing pressing issues like; what is the current trend of both intra and inter African student and staff mobility in higher education in the region? How do the continental initiatives already in place to promote student and academic mobility work? What are the challenges and prospects of academic mobility in Africa? Recent developments in the area have also been described through quantitative and qualitative data generated from primary and secondary sources.