Working in silos or working within one discipline has not improved the delivery of healthcare. With a goal to advance the healthcare quality agenda and in response to an identified need within both the educational and healthcare sector, Queen's University has established a Master's degree in Healthcare Quality [MSc(HQ)]. The interprofessional MSc(HQ) offers Canadian and international perspectives on quality, risk, and safety in healthcare using both practical and theoretical perspectives. This paper outlines pedagogical principles and approaches, and provides preliminary evidence of the effective mix of theoretical and practical underpinnings. These preliminary findings indicate that the students have entered our program with a minimal understanding of quality and patient safety and our program has expanded their comprehension. Students have claimed to feel more confident that they can apply patient safety principles in their workplace. By engaging a wide interprofessional perspective we can advance the system.