Introduction: Investigation into the factor structure of Domains of Creativity Scale has been on for sometimes now. The purpose of this study was to test the validity of the Kaufman Domains of Creativity Scale on Nigerian preservice science, technology, and mathematics teachers. Method: Exploratory and confirmatory factor analyses were performed on the responses of 337 preservice science, technology, and mathematics teachers to the Kaufman Domains of Creativity Scale. Results: Results of both analyses supported the five-factor structure of the Kaufman Domains of Creativity Scale: Mechanical/Scientific, Scholarly, Performance (encompassing writing and music), Self/Everyday, and Artistic. Construct validity of the Kaufman Domains of Creativity Scale was supported by its relationships with the Big Five Inventory in ways that were predicted by theory and consistent with previous research. Coefficient alphas and coefficients of congruence were generally strong. Discussion and Conclusion: The present study provided incremental validity to the multidimensional nature of the Kaufman Domains of Creativity Scale thus reinforcing the five-factor model namely Mechanical/Scientific, Scholarly, Performance (encompassing writing and music), Self/Everyday, and Artistic. Additionally, a Nigerian version of the 50-item Kaufman Domains of Creativity Scale in the three major indigenous languages: Hausa, Igbo, and Yoruba need to created and tested among undergraduate and postgraduate students in Nigerian institutions of higher learning.